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In this paper, the parameters of the mixed gamma with m components were estimated using model assuming that the variables are not dependent. The method used includes the ideas of the (Wilson-Hilferty (WH) approximation), the (MCLUST) formula, and (the ML principle). The complexities related to parameter estimation and mixture quantitative relation determination area unit reduced thanks to incorporation of a The Wilson-Hilferty approximation (WH) that converts to multivariate Gaussian mixture (MGMM) setup. This methodology was wont to estimate the rate of spleen enlargement in patients with thalassemia (anemia Mediterranean Sea).